W8

Lab weighing and sorting for

organoids and spheroids

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From quality control to drug activity effect, from compactness-related data to highlighting permeation, the W8 represents a novel approach to cover worldwide claimed scientific gaps related to the need for improvements in 3D cell cultures.

Uniformity and standardization, as well as growth monitoring and protocol modifications effects, have been challenging for researchers.

The W8 not only gives new perspectives on such aspects, but it does so label-free, with preserved sterility and viability and allowing a unique biophysical-based sorting of the subpopulation suitable to continue your workflow.

We think it is time to cross the state of the art.

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Designed by engineers, intended for researchers

W8 is conceived to perform the biophysical characterization of 3D cellular models,  in terms of mass density, weight, and size. All that in a small, easy-to-use, and plug&play analytical tool.

Flexible in size and type

Whether you are culturing cancer spheroids or organoids,  cellular aggregates, between 50 and 500 microns in diameter, can be processed.

Gentle sorting

The size- or mass-density-based sorting function allows recovering targeted spheroids’ sub-populations, label-free and with preserved viability and sterility, minimizing shear stress, for further downstream analysis.

Unparalleled, superior performances

The method allows to obtain solid data with proven mass density sharp precision (< 0.1%) and accuracy (< 1.0%).

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A QC Assay for standardization in 3D cell culture

W8 provides a lable-free, non-invasive method for monitoring and quantifying the biophysical properties of 3D cellular culture.
Gathering precise information on their size, weight, and mass-density values are crucial to support decisions for protocol optimization and sorting of the best culture conditions.

Physical-based sorting and recovery of pure, viable spheroids

The automated sorting and flow-based recovery allow the harvesting of spheroids’ subsets under sterile conditions and without compromising sample viability. 

Label-free, biophysical markers of in vitro drug efficacy

Imaging of thick 3D cell models doesn’t come without problems. Therefore, the label-free measurement of spheroids’ biophysics represents a key step forward to accurate testing of new molecular entities. While weight loss and diameter shrinkage are coherently related to apoptosis and viability decrease, mass density proves to be a valuable marker linked to drug toxicity.

A new preclinical marker of cell-based immunotherapy

Immunotherapy constitutes an ever-growing trend in cancer treatment. Having a quantitative, easy assay for evaluating the in vitro efficacy would tremendously help bring together relevant insights in preclinical research. W8 introduces a new method to quantify the infiltration rate and killing efficacy of immune cells.

Publications

A Reliable Flow-Based Method for the Accurate Measure of Mass Density, Size and Weight of Live 3D Tumor Spheroids.

Cristaldi et All 2019

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The patented method of automated Physical Characterization of Colorectal Cancer Spheroids and Evaluation of NK Cell Infiltration Through a Flow-Based Analysis.

Sargenti et All 2020

A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib.

Sargenti et All 2021

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Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis.

Cianciosi et All 2022

Development of a high-throughput micropatterned agarose scaffold for consistent and reproducible hPSC-derived liver organoids.

Shanqing Jiang et All 2023

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Characterization of Perinatal Stem Cell Spheroids for the Development of Cell Therapy Strategy.

Paris et All 2023

Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS.

De Simone et All 2023

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A viability study of 3D tumor spheroids after their mass-density characterization via an innovative flow-based biophysical method

Bacchi et All 2021

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