We all know the high costs required to bring a drug to market and the high failure rate of potential compounds. In fact, the discovery of a new medicine requires more than 1,5 billion dollars and can take 12/15 years of research efforts. Research demands for new experimental models ensuring more predictive approaches, to better understand the fate of a drug before going into clinical trials.
Cells are not equally abundant, some of them are even rare, which makes it difficult to study them. Existing technologies already allow their isolation, selection and DNA analysis. What is missing, but definitely very much needed, is a laboratory tool allowing the performance of in-vivo imaging analyses (microscopy) of rare cells, taking into consideration that they are limited in number and difficult to manage.
Despite the large number and the high costs of in-vitro fertilization treatments, only 1/3 of them are successful. It is proven that the first 4 days of embryo development are crucial; it is therefore necessary, since the very first stages, to cultivate embryos having the possibility to change and adapt biological conditions, as if they were developing in the mother’s apparatus. Monitoring embryo development through time-lapse imaging becomes equally essential to select the best ones to be then implanted.