CELLviewer is an automated Lab-On-a-Chip platform consisting of a 3D culture system that combines time-lapse microscopy and microfluidic technologies to allow contamination-free in-vitro culturing and analysis of floating single cells and organoids/cellular aggregates.
CIRCULATING TUMOR CELLS
Isolation and detection of Circulating Tumor Cells (CTC) is a challenge in clinical oncology because of their extreme rarity and the mechanical stress the cells undergo during this process. New live CTC microfluidics-based identification and characterization technologies are needed to get reliable information on dynamic biological processes after drug administration.
ORGANOIDS AND 3D CELL CULTURE
Organoids and spheroids in suspension have shown many advantages in the results of in-vitro research. Thanks to a 3D in-vivo-like culturing environment, stem cell behavior is maintained and reliable investigation of crucial cellular processes (cell differentiation, morphogenesis, metamorphosis and organogenesis) is possible both at tissue and molecular level.
IN-VITRO FERTILIZATION & EMBRIOLOGY
In-vitro culturing conditions in which the embryo is grown affect the percentage of implantation and the survival of embryos that could achieve implantation. Monitoring and driving in-vitro fertilized embryo development in fallopian tubes-like microenvironment becomes essential to increase implantation rate and improve the quality of IVF treatments.
Today research absolutely needs 3D co-culturing systems, where cells can move, aggregate and even multiply. Since now, we could only take static pictures of cells, but with CellViewer I finally managed to observe co-culturing systems as they really are. I have believed in this technology since the beginning and I would highly recommend it.
Cells were not born to live isolated, but in populations of single cells. Scientists must be given the right tools to study populations of cells. In this sense, CellViewer represents a break-through capable of changing the paradigm of scientific research to improve its medical utility.
We are used to analyze cells adherent to the bottom of a well, but in nature embryos float. Thanks to CellViewer we were able to perform embryo cultures mimicking in-vivo physiological condition. Moreover, it allowed us to change the culturing media without taking out the embryo. This technology definitely represents a step forward in our sector, improving the quality of our job.